Non-invasive radiogenomic mapping of the SMARCAL1-driven ferroptotic niche is associated with longitudinal MRD-negative surveillance in early-stage NSCLC.

All four axes remained highly significant after conservative cross-family correction (all Holm-adjusted P < 2.5 × 10 -4 ), confirming that the convergent multi-omics signature associated with elevated Rad-Score — encompassing ferroptosis activation, effector immune infiltration, genomic instability, and spatially organized chemokine networks — is robust and independent of false-positive inflation across omics families.

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