RNA-binding protein transcripts reflect composition of target mRNAs.

While the statistical significance is lower than in the primary analysis under this stringent removal—which eliminates not just exact motif sequences but binding sites that loosely resemble them—the global correlations between mRNA nucleotide content and ICP remain qualitatively unchanged and highly significant for all four nucleotides ( P -values between 10− 41 and 10− 9 ; Supplementary Fig.

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