Topoisomerase III limits RecA-dependent DNA amplification in the chromosome terminus with RecG.

Nucleic Acids Res · 2026 · PMC13244152 · PMID 42258535

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highly significantno p-value reported

We consider the observation that 14.1% of topA topB null cells contain at least one DSB to be highly significant, given the major consequences of DSBs for genomic instability, including their potential to promote antibiotic resistance in bacteria, and the nearly 25-fold higher frequency observed relative to wild-type cells.

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