Key determinants for lowering the risk of joint replacement in weight-bearing joints: a population-based cohort study.

Although after adjusting for OA, the observed association between P1NP and JR risk was attenuated to borderline significance, likely reflecting shared variance, as OA progression involves bone remodelling processes captured by P1NP.

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Although both associations were borderline significant, the direction of effect suggests BMI reduction in midlife may confer protection, whereas in older adults, low BMI may be linked to a higher risk (Table 5 ).

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