borderline significanceP = 0.03
aeruginosa eradication (downgraded for inconsistency due to I2 = 52%), low for change in sputum bacterial density (downgraded for inconsistency and suspected publication bias), moderate for change in FEV1% predicted (downgraded for imprecision due to small sample size), low for number of hospital admissions and days of hospital admission (downgraded for imprecision due to very small sample size, n = 90), very low for exacerbations (downgraded for inconsistency, imprecision, and indirectness), low for clinical improvement (downgraded for inconsistency and imprecision, noting the borderline significance of P = 0.03 and the fragile 95% CI of 1.06 to 3.21), moderate for non-fatal adverse events and respiratory non-fatal adverse events (downgraded for imprecision), and low for tobramycin resistance (downgraded for imprecision due to limited sample size and short follow-up duration).