Biophysical and biochemical studies support PHD inhibitor development as a TPI deficiency therapy.

J Cell Sci · 2026 · PMC13245896 · PMID 41949155

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highly significantno p-value reported

As before, we saw a highly significant increase in FB909 TPI protein levels after vadadustat treatment; however, this increase was not enough to bring protein levels up to that of WT or even to that of untreated FB755 cells.

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