Negative allosteric modulator of the metabotropic glutamate receptor 7 ADX71743 increases wakefulness, reduces sleep, and alters stress-induced changes in the brain neurotransmitter levels.

15 Specifically, a novel, selective orthosteric-like antagonist of mGlu 7 , HAP044 (7-hydroxy-3-(4-iodophenoxy)-4H-chromen-4-one), administered chronically, resulted in highly significant reductions in the effect of chronic psychosocial stress on hypothalamic–pituitary–adrenal axis dysfunctions and stress-mediated exacerbation in anxiety-like reactivity. 15 To achieve this goal, we used the in vivo microdialysis technique to measure the basal and mild stress-induced changes in extracellular concentrations of glutamate (Glu), γ-aminobutyric acid (GABA), glycine (Gly), serotonin (5-hydroxytryptamine; 5-HT), norepinephrine (NE), and dopamine (DA) in freely moving rats.

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