Increasing proportion and more favourable outcomes of seronegative rheumatoid arthritis: analysis of the IORRA cohort from 2000 to 2021.

Clin Rheumatol · 2026 · PMC13249915 · PMID 42050091

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an increasing trendno p-value reported

This uncertainty stems from the limited geographic coverage, the fact that not all studies showed an increasing trend, the small number of cases included, and the lack of a consistent definition of seronegative RA (defined as negative anti-CCP or negative RF).

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