highly significantp < 0.0001
Model Adequacy, ANOVA, and RSM Optimization The results of analysis of variance (ANOVA) (Table 4 ) demonstrated that all three quadratic models were highly significant, as indicated by large F ‐values (TPC: 71.54; DPPH: 59.86; reducing power: 101.76) and very low p ‐values ( p < 0.0001).