Pro-inflammatory intestinal Th17-cells are tissue-resident, accumulate in the epithelia in Crohn's disease, and predict unresponsiveness to vedolizumab.

J Crohns Colitis · 2026 · PMC13250732 · PMID 42267895

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highly significantno p-value reported

GSEA confirmed a highly significant enrichment of pTh17 signature genes in the Th17 cluster and of cTh17 signature genes in the T CM cluster ( Figure 1E ).

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