Adaptive Disorder as the Hallmark of Nanobodies Antigen-Binding Loops.

J Chem Inf Model · 2026 · PMC13250985 · PMID 42170950

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highly significantp < 2.2 × 10 –16actually significant

A one-way ANOVA confirmed that the differences among residue classes are highly significant ( F (3, 14,983) = 682.6, p < 2.2 × 10 –16 ), supporting the hypothesis that CDR loops correspond to weakly coupled, energetically uncoupled regions when compared to the structural core of nanobodies.

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