A subset of hepatic fibroblasts marked by Gli1 expression generates portal fibrosis and promotes ductular reaction.

JHEP Rep · 2026 · PMC13251686 · PMID 42025801

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highly significantno p-value reported

Ablation of the majority of Gli1+ cells almost completely inhibited portal fibrosis 1 week after the onset of biliary injury and caused an inhibition of the ductular reaction, which was highly significant in the DDC model.

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