High-fat diet is associated with accelerated gray matter atrophy in cognitively unimpaired older adults but slower atrophy in individuals with existing mild cognitive impairment.

Although the interaction tests failed to achieve significance, higher Pfat was significantly associated with a slower rate of enlargement of the inferior lateral ventricle in APOE ε4 carriers ( β = −36.0, p = 0.003) and/or female individuals ( β = −28.4, p = 0.005) (Table S4 ). 4.

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