Two large population-based studies demonstrated the high frequency of polypharmacy in the ASD population, sitting at around 30%, and confirmed that SSRIs account for a relevant percentage of prescriptions (5.6% for fluoxetine and 5.5% for sertraline) with an increasing trend over the years 25 , 26 Why It Is Important To Do This Review To date, a Cochrane Systematic review published in 2013 27 has examined the efficacy of 4 SSRIs (fluoxetine, fluvoxamine, fenfluramine and citalopram) in both adult and children populations.
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Selective Serotonin Reuptake Inhibitors for Children with Autism Spectrum Disorder: A Systematic Review and Meta-Analysis.
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