Ribosome Biogenesis as a Putative Bottleneck to Skeletal Muscle Hypertrophy: Mechanisms, Human Evidence, and Practical Modulators.

Cells · 2026 · PMC13256862 · PMID 42274633

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This massive c-Myc induction precedes and obligatorily drives a subsequent, highly significant elevation in 45S pre-rRNA, which typically peaks between 4 and 12 h post-exercise before gradually returning to baseline [ 85 , 86 ].

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