highly significantp = 2.54 × 10 −3
These alterations were highly significant: in ZNF441 -mutant ( p = 2.54 × 10 −3 ), in LAMB3 -mutant ( p = 5.16 × 10 −3 ), PNPLA6-mutant ( p = 3.00 × 10 −3 ), and in LNX1-mutant tumors ( p = 5.16 × 10 −3 ).
These alterations were highly significant: in ZNF441 -mutant ( p = 2.54 × 10 −3 ), in LAMB3 -mutant ( p = 5.16 × 10 −3 ), PNPLA6-mutant ( p = 3.00 × 10 −3 ), and in LNX1-mutant tumors ( p = 5.16 × 10 −3 ).
Here, the hazard ratio above 1 suggests a possible trend toward worse outcomes with high expression, but the wide confidence interval crossing 1.0 and the high p -value indicate substantial uncertainty.
However, the relatively small number of patients at risk at later time points may limit statistical power and contribute to the borderline significance.