Structural and functional hepatic factors as prognostic indicators in children with Langerhans cell histiocytosis.

After adjustment, hypoalbuminemia remained an independent predictor of inferior EFS (HR 4.40; 95% CI, 1.52–12.7; p = 0.003), while elevated direct bilirubin showed a nonsignificant trend toward poorer outcomes (HR 2.52; 95% CI, 0.94–6.75; p = 0.056) ( Table 4 ). 3.7 Extent of hepatomegaly and survival in patients with preserved liver function Among patients with hepatomegaly and preserved liver function, outcomes were further examined according to the degree of liver enlargement.

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