Xtr-mediated regulation of 4Fe-4S binding protein gene confers resistance to oxidative and antibiotic stress in <i>Clostridioides difficile</i>.

Further Gene Ontology (GO) analysis ( Figure 5D ) revealed a highly significant enrichment of oxidoreductase activity. 4Fe-4S_BP , which encodes a 4Fe-4S-binding domain protein, exhibits a highly conserved β-barrel fold typical of this protein class and contains a well-defined, structurally stable pocket for coordinating iron-sulfur clusters ( Supplementary Figure S6 ).

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