Molecular dynamics simulations for understanding dual ubiquitination mechanisms to consider S-phase kinase-associated protein 2 (SKP2) as a potential drug target in breast cancer.

Front Chem · 2026 · PMC13260631 · PMID 42292664

Europe PMC DOI

hedged sentence

—

closest p

—

boldest claim

The sentences

highly significantno p-value reported

For the SKP2-p27 interaction, Cluster 2 was identified as the most probable binding pose, exhibiting a HADDOCK score of −103.8 ± 7.8 and a highly significant Z-score of −2.0.

also in 132,142 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.