highly significantP < 2.2 × 10 − 16
Conversely, IL-6 exhibited highly significant positive correlations with the other 11 states, including EMT ( P < 2.2 × 10 − 16 ), inflammation ( P < 2.2 × 10 − 16 ), invasion ( P < 2.2 × 10 − 16 ) and metastasis ( P < 2.2 × 10 − 16 ).