Identification of disease-specific regulatory networks in prurigo nodularis versus atopic dermatitis through ATAC/RNA single-nucleus profiling.

J Allergy Clin Immunol · 2025 · PMC13261850 · PMID 40939757

Europe PMC DOI

hedged sentence

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closest p · 0.0× alpha

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highly significantP < 2 × 10 −16actually significant

Our results also showed that nemolizumab significantly normalized the transcriptional profiles of PN lesional skin, especially in differentiated keratinocytes, fibroblasts, and follicle cells, with highly significant changes ( P < 2 × 10 −16 ).

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