JAK Activation Drives MED15-Associated Melanocyte Dysfunction in Vitiligo Beyond Immune Cells.

Consistent with the CCK-8 results, MED15 overexpression triggered a profound pro-apoptotic response, evidenced by a highly significant increase in Caspase-3/7 activity compared to the Mock group ( Figure 3C , P < 0.01).

also in 132,142 other papers

Genes that remained significant after conditioning were defined as “jointly significant”, whereas those that lost significance were defined as “marginally significant”.This procedure helped disentangle overlapping signals and prioritize potentially causal genes.

also in 26,082 other papers