End-stage valvular heart disease requiring heart transplantation: risk profile, surgical modifiers, and myocardial pathology.

BMC Cardiovasc Disord · 2026 · PMC13267388 · PMID 42050441

Europe PMC DOI

hedged sentence

0.0610

closest p · 1.2× alpha

0.0610

boldest claim

The sentences

borderline significanceP = 0.061so close (0.05 < p ≤ 0.1)

Female sex (HR 2.44, 95% CI 1.071–5.555, P = 0.034), age at MACEs (HR 0.84, 95%CI 0.794–0.896, P < 0.001), refractory HF with/without arrhythmia (HR 3.32, 95%CI 1.187–9.274, P = 0.022), and atrial fibrillation (HR 0.31, 95%CI 0.138–0.705, P = 0.005) were significantly associated with timing of HTx, whereas cardiac valvular surgery showed borderline significance ( P = 0.061).

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