Pathogenic mechanisms of <i>RPGR</i> mutations in X-linked retinitis pigmentosa: integrating clinical pedigree and single-cell transcriptomics.

Through direct comparison of the cellular composition between the control and RPGR mutant groups at matched time-points, we observed that during the late developmental stages (D150 and D200), the RPGR mutant organoids showed an increasing trend in the transcriptional activity or relative cellular abundance of photoreceptor cells, such as cones and rods ( Figure 4C ).

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