High-salt diet promotes atopic dermatitis by partially enhancing intestinal SGK1/ENaC signaling and destroying gut <i>Lactobacillus</i>-maintained systemic type 1 interferon.

Compared with the sting ( f/f ) mice, cKO of sting in DCs also significantly upregulated the epidermal thickness and the serum IgE and IL-4/IL-13, but reduced the serum IFN1; however, the change degrees in these indicators were not as significant as those observed under the condition of pDC deletion ( Figures 3A–D ).

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