A negative APC corresponds to a decreasing trend, and a positive APC corresponds to an increasing trend.
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Incidence of Recurrent Respiratory Papillomatosis (RRP) in Denmark and Sweden During 2000-2023: Two Nationwide Cohort Studies in Children and Young Adults.
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Danish data showed a decreasing trend in RRP during the period following implementation of HPV vaccination, especially among young adults (women: APC = −11.5 [95% CI, −20.9 to −0.9]; men: APC = −11.0 [95% CI, −16.6 to −4.9]), whereas Swedish data did not show any clear decrease in RRP over time.