Anti-spike IgG Avidity Enhances Neutralization of Severe Acute Respiratory Syndrome Coronavirus 2: A Prospective Study of Primary Infections and Immunizations.

J Infect Dis · 2026 · PMC13271396 · PMID 41784399

Europe PMC DOI

hedged sentences

0.0530

closest p · 1.1× alpha

0.0530

boldest claim

The sentences

did not quite reach statistical significanceP = .053so close (0.05 < p ≤ 0.1)

Effect of Wuhan S-IgG avidity for heterologous nAb levels against the Delta variant did not quite reach statistical significance in general ( P = .053; Table 3 ) but was significant for nonhospitalized patients ( P = .002; Supplementary Table 2 ), suggesting a putative effect.

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a decreasing trendno p-value reported

During follow-up, all antibody levels showed a decreasing trend in both patient groups ( Figures 3 and 4 , Supplementary Figures 2 and 3 ).

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