AKAP1 enhances glycogen accumulation and hepatocarcinogenesis through YTHDF2-mediated G6PC mRNA decay.

Moreover, the univariate and multivariate Cox regression analyses (Supplementary Tables 10 and 11 ) identified aberrant AKAP1, YTHDF2, and G6PC expression levels as independent prognostic factors for OS in HCC patients, whereas MAZ showed a nonsignificant trend toward being an independent prognostic factor (HR = 1.209, 95% CI: 0.895–1.633, P = 0.217), which is in line with the study by Li et al. 19 To clinically translate these findings, we developed a nomogram integrating the gene signature with key clinicopathological parameters (Supplementary Fig. 19a ).

also in 5,406 other papers