Pan-organ poly(A) atlas reveals a post-transcriptional regulatory layer independent of RNA abundance.

Nat Commun · 2026 · PMC13273047 · PMID 41991903

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highly significantno p-value reported

This principle holds true system-wide, as a Fisher’s Exact Test against the MouseNet v2 functional interaction database revealed a highly significant enrichment of known functional interactions within the poly(A)-specific group of co-clustered isoform pairs when compared to the background of non-co-clustered pairs (Odds Ratio = 1.65, Bonferroni-corrected p = 2.89×10 -62 ; Fig. 4E ).

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