A similar trend was also observed in caspase1/11-null mice, but did not achieve significance (Fig. 7c, g, h ) presumably because of the high variances in the data, which can arise from differences in the orientation and depth of tissue sectioning (i.e., sampling error) as well as a smaller n.
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A broad cathepsin inhibitor blocks crystal-stimulated inflammasome-dependent and -independent inflammation and gout arthritis.
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