highly significantP < 0.01
A significant difference ( P < 0.05) was observed as early as day 2, and this difference became highly significant ( P < 0.01) from day 3 to day 5.
A significant difference ( P < 0.05) was observed as early as day 2, and this difference became highly significant ( P < 0.01) from day 3 to day 5.