Immunogenetic modulation of endothelial inflammation by the LIPG -384A/C promoter variant influences COVID-19 severity.

Severity trend and binary association analyses Cochran–Armitage trend test revealed a highly significant inverse relationship between the EL-384A/C variant and COVID-19 severity ( Table 6 ): Genotype trend (AC vs.

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While the variant did not influence overall susceptibility to SARS-CoV-2 infection, the C allele appeared to be protective against disease severity, showing a decreasing trend from mild to critical cases.

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