Circulatory microRNA signature distinguishing rheumatoid arthritis and psoriatic arthritis.

Functional pathway analysis of the three significantly different miRNAs demonstrating greatest separation between RA and PsA While a highly significant difference in the expression of seven miRNAs between RA and PsA was identified, further biplot analysis of PCA and logplot of normalized miRNA expression demonstrated that the miRNA expression distribution was mainly associated with a dominant skew towards three specific miRNA in RA vs PsA: miR-29b-3p ( P ≤ 0.0001), miR-22-3p ( P ≤ 0.0001) and miR-223-3p ( P ≤ 0.05) ( Fig. 5A ).

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