Plasma metabolomic and lipidomic signatures characteristic of treatment non-response in rheumatoid arthritis.

Front Immunol · 2026 · PMC13275419 · PMID 42327779

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an increasing trendno p-value reported

Notably, several metabolite clusters showed an increasing trend as the disease advanced: NEG metabolites in Clusters 1, 7, and 12; POS metabolites in Clusters 2, 7, and 10; NEG lipid species in Clusters 3, 6, and 7; and POS lipid species in Clusters 1 and 7 ( Figure 2 ).

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