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Better adherence to the life's essential 8 can reduce the risk of gallstone disease: mediated by inflammation and oxidative stress.

Front Public Health · 2026 · PMC13275442 · PMID 42326954

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a decreasing trendno p-value reported
Specifically, as the LE8 score increases, the overall risk of GSD shows a decreasing trend, but this decline exhibits varying rates across different score intervals.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.