White adipose atrophy exacerbates cold stress and accelerates aging in male mice.

Nat Commun · 2026 · PMC13276256 · PMID 42000736

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a mild trendno p-value reported

Intriguingly, 8-m-old male Lmna f/f ;AC mice exhibited a mild trend toward reduced average adipocyte size at room temperature (RT) (Fig. 4e ), accompanied by reduced mRNA levels of Ucp1 , Pgc1a , and Pparg in iWAT (Fig. 4g ).

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