Maternal High-Fat Diet Worsens Necrotizing Enterocolitis via Effects on Mitochondrial Function in Newborn Mice.

As shown in Figure 4D‒G , while tumor necrosis factor a (Tnfa) and interleukin 6 (Il6) showed a nonsignificant trend towards increased expression in the HFD-NEC group as compared with the STD-NEC group by 2-way analysis of variance (ANOVA), there was a statistically significant increase in the serum expression of both interleukin-10 (IL-10) and interferon-gamma-induced protein 10 (Ip10) in the serum in the HFD-NEC group compared with the STD-NEC controls, consistent with a heightened inflammatory response in the HFD group.

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