Evolutionary programming as a platform for in silico metabolic engineering.

BMC Bioinformatics · 2005 · PMC1327682 · PMID 16375763

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an increasing trendno p-value reported

Currently there is an increasing trend to replace chemical synthesis processes with biotechnological routes based on microbial fermentations.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.