HIF-2α drives osteoarthritis progression via suppression of the HDAC4-ATF4-CHOP signaling axis.

PLoS One · 2026 · PMC13278430 · PMID 42313796

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a decreasing trendno p-value reported

Compared with the AAV9-HIF-2α-NC group, the AAV9-HIF-2α group showed a decreasing trend in MMP activity at 8 weeks, which became significantly lower by 12 weeks.

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