Barely Significant
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Metformin attenuates diabetic osteoporosis via the miR-21 mediated Mef2c/Sost pathway.

Front Endocrinol (Lausanne) · 2026 · PMC13278933 · PMID 42325620

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a decreasing trendP > 0.05actually significant
miR-21 -/- mice showed significantly decreased bone stiffness and maximum load relative to NC mice ( P < 0.05), with the failure load exhibiting a decreasing trend ( P > 0.05) ( Figure 3A ).

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