Chemerin Activation of Toll-Like Receptor 4 Drives Mineralocorticoid Receptor-Mediated Aortic Valve Remodeling in Chronic Kidney Disease.

J Am Heart Assoc · 2026 · PMC13279188 · PMID 41990319

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a decreasing trendno p-value reported

With the exception of Bmp4 expression, which showed a decreasing trend, and Col1a1 expression, which exhibited a near‐significant inhibition, all other effects were significantly blocked by the nonsteroidal MRA finerenone, demonstrating the involvement of MR signaling.

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