An acetylated Tau-174 CSF biomarker discriminates between TDP-43 and tau pathology in patients with frontotemporal lobar degeneration.

Nat Med · 2026 · PMC13279261 · PMID 41986736

Europe PMC DOI

hedged sentence

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

borderline significantP = 0.06so close (0.05 < p ≤ 0.1)

Findings from the UPenn cohort supported the prognostic value of CSF AcTau174 in FTLD-TDP; higher baseline AcTau174 was associated with a faster rate of cognitive decline as measured by MMSE, although this association was borderline significant ( β = −1.63; 95% CI = −3.25, −0.05, P = 0.06; Fig. 3c and Extended Data Table 3 ).

also in 11,409 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.