Microbiome signature of Parkinson's disease in healthy and genetically at-risk individuals.

Notably, all GBA-NMC individuals who were identified as prodromal PD, based on the MDS research criteria 16 , had the abundance of coherent PD-enriched species above the median, a highly significant bias ( χ 2 test, P = 4.7 × 10 −3 ), and four were at the very top of the distribution (Fig. 3 ; P = 5.7 × 10 −4 ).

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