Development and Validation of an m6A-Derived Prognostic Signature in Lung Adenocarcinoma.

These analyses revealed two distinct correlational patterns: the top 5 drugs negatively correlated with RiskScore (TANK_1366_1461, IAP_7638_1429, S-Trityl-L-cysteine_41, Bosutinib_1019 and Tozasertib_32) showed a decreasing trend in predicted IC50 as RiskScore increased, implying that HR group may theoretically be more sensitive to these agents; in contrast, the top 5 drugs positively correlated with RiskScore (Trichostatin-A_437, MK-2206_1053, Ara-G_427, GSK690693_326 and WZ3105_252) exhibited a decrease in predicted IC50 as RiskScore decreased, indicating that the LR group may have theoretical sensitivity advantages to these positively correlated chemotherapy drugs.

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