The prucalopride group tended to make correct choices more quickly although the group × reaction time interaction fell short of significance [group × mean reaction time: F (1,44) = 3.17, p = 0.082]; see Figure 2d and Supplementary Table S5 .
However, in the prucalopride group, there was a borderline significant difference between the groups in terms of positive affect at the post-intervention research visit, with higher scores in the prucalopride group compared with the placebo group [PANAS-P mean (SD): placebo 29.1 (6.98), prucalopride 33.2 (7.35), t (46.6) = −1.99, p = 0.05, Cohen’s d = −0.57 (−1.14, 0.00)], which was not wholly explained by PANAS scores at baseline (see Table 1 )].