Integrated Transcriptomic and Single-Cell Analyses Link ATP7A, a Cuproptosis-Related Hub Gene, to ECM-Adhesion Signaling Dysfunction in UVB-Induced Skin Photodamage.

Clin Cosmet Investig Dermatol · 2026 · PMC13281878 · PMID 42328487

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highly significantP < 0.01actually significant

ation within the superficial and middle dermal layers following UVB exposure ( Figure 6 ). Relative mRNA Expression Levels of Inflammatory Factors in UVB-Induced Photodamage Cell and Mouse Models In the UVB cell model, IL-1β expression was markedly elevated ( P < 0.05), while IL-6 and TNF-α showed highly significant upregulation ( P < 0.01) versus the control group.

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