Joint association of atherogenic index of plasma and estimated glucose disposal rate with new-onset cardiovascular disease risk in individuals with cardiovascular-kidney-metabolic syndrome stages 0-3: a 9-year nationwide prospective cohort study.

Addressing this gap in evidence is practically significant, as clinical decision-making during CKM stages 0–3 predominantly relies on low-cost, scalable stratification tools, rather than complex tests that are challenging to routinely implement in primary care settings.

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In contrast, eGDR exhibited a decreasing trend in CVD and heart disease risk, followed by a plateau, and a more linear decrease in stroke risk.

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