ERBB2/HER2 landscape and prognostic impact: large-scale, real-world analysis across solid cancers.

ESMO Open · 2026 · PMC13285824 · PMID 42296698

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highly significantno p-value reported

Overall, the strongest statistical associations between HER2 expression and ERBB2 mutations appeared in small intestinal malignancies, cancer of unknown primary (CUP), and breast carcinoma, all with highly significant Q values after Bonferroni correction.

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an overall trendno p-value reported

There was an overall trend of increasing ERBB2 mutation prevalence with higher HER2 expression, with a marked increase from 2.03% in HER2 IHC 0+ to 4.53% in 3+ cases ( Table 2 ).

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