Clinical Characterization of a Multicenter International Cohort of Patients With Aicardi-Goutières Syndrome Homozygous for the RNASEH2B:p.Ala177Thr Variant: Early Clinical Markers of Disease Severity.

Pediatr Neurol · 2025 · PMC13286056 · PMID 40812004

Europe PMC DOI

hedged sentences

0.0968

closest p · 1.9× alpha

0.0968

boldest claim

The sentences

a trend toward significanceP = 0.0968so close (0.05 < p ≤ 0.1)

A trend toward significance was also observed between the moderate and severe groups ( P = 0.0968) ( Fig 1 ).

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trending toward significanceno p-value reported

21 Microcephaly, although only trending toward significance in our cohort, has been previously identified as a negative prognostic factor in AGS 8 and may further contribute to clinical stratification.

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