Peripheral B cell immune dysregulation genetically contributes to stage-dependent neuroinflammation and identifies priority therapeutic targets in Parkinson's disease: a computational integration of Mendelian randomization and single-cell transcriptomics.

The inferred B-cell-related communication intensity showed an increasing trend from 1.07 in HC to 1.43 in PD-Early and 1.91 in PD-Late.

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The proportion of B cells showed a decreasing trend across the three PBMC groups, from 9.0% in the HC group, through 7.8% in the PD-Early group, to 6.1% in the PD-Late group ( Figure 2A ).

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